Activity of trastuzumab emtansine (T-DM1) in 3D cell culture

BACKGROUND: Cell spheroids and aggregates generated from three-dimensional (3D) cell culture methods are similar to in vivo tumors in terms of tissue morphology, biology, and gene expression, unlike cells grown in 2D cell cultures. Breast cancer heterogeneity is one of the main drug resistant mechan...

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Опубликовано в: :Breast Cancer Res Treat
Главные авторы: Boyer, Jean Zheng, Phillips, Gail D. Lewis, Nitta, Hiro, Garsha, Karl, Admire, Brittany, Kraft, Robert, Dennis, Eslie, Vela, Elizabeth, Towne, Penny
Формат: Artigo
Язык:Inglês
Опубликовано: Springer US 2021
Предметы:
Preclinical Study
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233276/
https://ncbi.nlm.nih.gov/pubmed/34091830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-021-06272-x
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