Loss of PKA regulatory subunit 1α aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury

Reperfusion therapy, the standard treatment for acute myocardial infarction, can trigger necrotic death of cardiomyocytes and provoke ischemia/reperfusion (I/R) injury. However, signaling pathways that regulate cardiomyocyte necrosis remain largely unknown. Our recent genome-wide RNAi screen has ide...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Liu, Yuening, Chen, Jingrui, Xia, Peng, Stratakis, Constantine A., Cheng, Zhaokang
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233231/
https://ncbi.nlm.nih.gov/pubmed/34087234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100850
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