Identification of peptidomimetic telomere dysfunction inhibitor (TELODIN) through telomere dysfunction-induced foci (TIF) assay

Telomere dysfunction-induced focus (TIF) assay allows efficient profiling of telomere dysfunctions in cells and tissues. Here, we describe the use of the TIF assay to screen synthetic peptides from E3 ubiquitin ligase FBW7, a tumor suppressor gene product, to prevent TIFs caused by environmental rad...

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Bibliographic Details
Published in:STAR Protoc
Main Authors: Wang, Lihui, Wang, Zhiguo, Liu, Jun-Ping
Format: Artigo
Language:Inglês
Published: Elsevier 2021
Subjects:
Protocol
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233158/
https://ncbi.nlm.nih.gov/pubmed/34195674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2021.100620
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