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Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials

Simulation studies have shown that novel designs such as the continual reassessment method and the Bayesian optimal interval (BOIN) design outperform the 3 + 3 design by recommending the maximum tolerated dose (MTD) more often, using less patients, and allotting more patients to the MTD. However, it...

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Bibliografiska uppgifter
I publikationen:JCO Precis Oncol
Huvudupphovsmän: Silva, Rebecca B., Yap, Christina, Carvajal, Richard, Lee, Shing M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wolters Kluwer Health 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232832/
https://ncbi.nlm.nih.gov/pubmed/34250415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.21.00136
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