Embracing model-based designs for dose-finding trials

BACKGROUND: Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose finding, such as the continual reassessment method (CRM). METHODS: We carried out a literature review of dose-fi...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Love, Sharon B, Brown, Sarah, Weir, Christopher J, Harbron, Chris, Yap, Christina, Gaschler-Markefski, Birgit, Matcham, James, Caffrey, Louise, McKevitt, Christopher, Clive, Sally, Craddock, Charlie, Spicer, James, Cornelius, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537496/
https://ncbi.nlm.nih.gov/pubmed/28664918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.186
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