A Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats

BACKGROUND: Duvelisib (DUV) is a new oral phosphoinositide-3-kinase (PI3K)-δ and PI3K-γ inhibitor. It has been recently granted an accelerated approval for treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It is also effe...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Sayed, Ahmed Y, Khalil, Nasr Y, Almomen, Aliyah, Alzoman, Nourah Z, Almehizia, Abdulrahman A, Darwish, Ibrahim A
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232391/
https://ncbi.nlm.nih.gov/pubmed/34188446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S318714
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