Skin vaccination with dissolvable microneedle patches incorporating influenza neuraminidase and flagellin protein nanoparticles induces broad immune protection against multiple influenza viruses

We generated self-adjuvanted protein nanoparticles of conserved influenza antigens and immunized mice via skin vaccination with dissolvable microneedle patches (MNPs) to increase the strength and breadth of immune responses. We produced M2e nanoparticles via ethanol desolvation, and double-layered N...

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Detalhes bibliográficos
Publicado no:ACS Appl Bio Mater
Main Authors: Wang, Ye, Li, Song, Dong, Chunhong, Ma, Yao, Song, Yufeng, Zhu, Wandi, Kim, Joo, Deng, Lei, Denning, Timothy L., Kang, Sang-Moo, Prausnitz, Mark R., Wang, Bao-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232372/
https://ncbi.nlm.nih.gov/pubmed/34179728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsabm.1c00240
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