n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway

Spinocerebellar ataxia type 3 (SCA3), a hereditary and lethal neurodegenerative disease, is attributed to the abnormal accumulation of undegradable polyglutamine (polyQ), which is encoded by mutated ataxin-3 gene (ATXN3). The toxic fragments processed from mutant ATXN3 can induce neuronal death, lea...

Fuld beskrivelse

Na minha lista:

Bibliografiske detaljer
Udgivet i:	Int J Mol Sci
Main Authors:	Lee, Jui-Hao, Lin, Si-Yin, Liu, Jen-Wei, Lin, Shinn-Zong, Harn, Horng-Jyh, Chiou, Tzyy-Wen
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2021
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8231882/ https://ncbi.nlm.nih.gov/pubmed/34199295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126339
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway

Lignende værker