Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical properties of the newly synthesised hybrid (3) dem...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Enzyme Inhib Med Chem
Κύριοι συγγραφείς: Salerno, Loredana, Vanella, Luca, Sorrenti, Valeria, Consoli, Valeria, Ciaffaglione, Valeria, Fallica, Antonino N., Canale, Vittorio, Zajdel, Paweł, Pignatello, Rosario, Intagliata, Sebastiano
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Taylor & Francis 2021
Θέματα:
Brief Report
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231349/
https://ncbi.nlm.nih.gov/pubmed/34167427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1928111
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