Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical properties of the newly synthesised hybrid (3) dem...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Salerno, Loredana, Vanella, Luca, Sorrenti, Valeria, Consoli, Valeria, Ciaffaglione, Valeria, Fallica, Antonino N., Canale, Vittorio, Zajdel, Paweł, Pignatello, Rosario, Intagliata, Sebastiano
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231349/
https://ncbi.nlm.nih.gov/pubmed/34167427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1928111
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