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Thermodynamic Origin of Differential Excipient-Lysozyme Interactions

Understanding the intricate interplay of interactions between proteins, excipients, ions and water is important to achieve the effective purification and stable formulation of protein therapeutics. The free energy of lysozyme interacting with two kinds of polyanionic excipients, citrate and tripolyp...

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Vydáno v:Front Mol Biosci
Hlavní autoři: Kalayan, Jas, Curtis, Robin A., Warwicker, Jim, Henchman, Richard H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226134/
https://ncbi.nlm.nih.gov/pubmed/34179093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.689400
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