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Energy-entropy prediction of octanol–water logP of SAMPL7 N-acyl sulfonamide bioisosters

Partition coefficients quantify a molecule’s distribution between two immiscible liquid phases. While there are many methods to compute them, there is not yet a method based on the free energy of each system in terms of energy and entropy, where entropy depends on the probability distribution of all...

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Detalhes bibliográficos
Publicado no:J Comput Aided Mol Des
Main Authors: Falcioni, Fabio, Kalayan, Jas, Henchman, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295089/
https://ncbi.nlm.nih.gov/pubmed/34244906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-021-00401-w
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