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Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury

RATIONALE: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR). Although changes in plasma sPRR levels have been reported in hypertension, the causal role of sPRR in blood pressure (BP) regulation is unknown. OBJECTIVE: Determine the role of sPRR i...

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Publicat a:Circ Res
Autors principals: Ramkumar, Nirupama, Stuart, Deborah, Peterson, Caitlin S., Hu, Chunyan, Wheatley, William, Cho, Jae Min, Symons, J David, Kohan, Donald E
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225587/
https://ncbi.nlm.nih.gov/pubmed/33890822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.317532
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