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Investigation of Intradomain Motions of a Y-Family DNA Polymerase during Substrate Binding and Catalysis
DNA polymerases catalyze DNA synthesis through a stepwise kinetic mechanism that begins with binding to DNA, followed by selection, binding, and incorporation of a nucleotide into an elongating primer. It is hypothesized that subtle active site adjustments in a polymerase to align reactive moieties...
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| Опубликовано в: : | Biochemistry |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8225418/ https://ncbi.nlm.nih.gov/pubmed/27685341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00878 |
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