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Single-molecule Investigation of Substrate Binding Kinetics and Protein Conformational Dynamics of a B-family Replicative DNA Polymerase

Replicative DNA polymerases use a complex, multistep mechanism for efficient and accurate DNA replication as uncovered by intense kinetic and structural studies. Recently, single-molecule fluorescence spectroscopy has provided new insights into real time conformational dynamics utilized by DNA polym...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Maxwell, Brian A., Suo, Zucai
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630881/
https://ncbi.nlm.nih.gov/pubmed/23463511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.459982
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