Enhancing Metabolic Imaging of Energy Metabolism in Traumatic Brain Injury Using Hyperpolarized [1-(13)C]Pyruvate and Dichloroacetate

Hyperpolarized magnetic resonance spectroscopic imaging (MRSI) of [1-(13)C]pyruvate metabolism has previously been used to assess the effects of traumatic brain injury (TBI) in rats. Here, we show that MRSI can be used in conjunction with dichloroacetate to measure the phosphorylation state of pyruv...

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Publicado no:Metabolites
Main Authors: DeVience, Stephen J., Lu, Xin, Proctor, Julie L., Rangghran, Parisa, Medina, Juliana A., Melhem, Elias R., Gullapalli, Rao P., Fiskum, Gary, Mayer, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225170/
https://ncbi.nlm.nih.gov/pubmed/34073714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11060335
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