Use of Hyperpolarized [1-(13)C]Pyruvate and [2-(13)C]Pyruvate to Probe the Effects of the Anticancer Agent Dichloroacetate on Mitochondrial Metabolism In Vivo in the Normal Rat

Development of hyperpolarized technology utilizing dynamic nuclear polarization has enabled the measurement of (13)C metabolism in vivo at very high SNR. In vivo mitochondrial metabolism can, in principle, be monitored with pyruvate, which is catalyzed to acetyl-CoA via pyruvate dehydrogenase (PDH)....

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Hlavní autoři: Hu, Simon, Yoshihara, Hikari A.I., Bok, Robert, Zhou, Jenny, Zhu, Minhua, Kurhanewicz, John, Vigneron, Daniel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480972/
https://ncbi.nlm.nih.gov/pubmed/22819176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mri.2012.05.012
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