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Use of Hyperpolarized [1-(13)C]Pyruvate and [2-(13)C]Pyruvate to Probe the Effects of the Anticancer Agent Dichloroacetate on Mitochondrial Metabolism In Vivo in the Normal Rat
Development of hyperpolarized technology utilizing dynamic nuclear polarization has enabled the measurement of (13)C metabolism in vivo at very high SNR. In vivo mitochondrial metabolism can, in principle, be monitored with pyruvate, which is catalyzed to acetyl-CoA via pyruvate dehydrogenase (PDH)....
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3480972/ https://ncbi.nlm.nih.gov/pubmed/22819176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mri.2012.05.012 |
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