Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity

We describe a mammalian cell-based assay to identify coronavirus 3CL protease (3CLpro) inhibitors. This assay is based on rescuing protease-mediated cytotoxicity and does not require live virus. By enabling the facile testing of compounds across a range of 15 distantly related coronavirus 3CLpro enz...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Resnick, Samuel J., Iketani, Sho, Hong, Seo Jung, Zask, Arie, Liu, Hengrui, Kim, Sungsoo, Melore, Schuyler, Lin, Fang-Yu, Nair, Manoj S., Huang, Yaoxing, Lee, Sumin, Tay, Nicholas E. S., Rovis, Tomislav, Yang, Hee Won, Xing, Li, Stockwell, Brent R., Ho, David D., Chavez, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223961/
https://ncbi.nlm.nih.gov/pubmed/33910954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02374-20
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