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A simplified cell-based assay to identify coronavirus 3CL protease inhibitors
We describe a mammalian cell-based assay capable of identifying coronavirus 3CL protease (3CLpro) inhibitors without requiring the use of live virus. By enabling the facile testing of compounds across a range of coronavirus 3CLpro enzymes, including the one from SARS-CoV-2, we are able to quickly id...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | bioRxiv |
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| Prif Awduron: | , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Cold Spring Harbor Laboratory
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7457602/ https://ncbi.nlm.nih.gov/pubmed/32869020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.29.272864 |
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