A simplified cell-based assay to identify coronavirus 3CL protease inhibitors

We describe a mammalian cell-based assay capable of identifying coronavirus 3CL protease (3CLpro) inhibitors without requiring the use of live virus. By enabling the facile testing of compounds across a range of coronavirus 3CLpro enzymes, including the one from SARS-CoV-2, we are able to quickly id...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:bioRxiv
Prif Awduron: Resnick, Samuel J., Iketani, Sho, Hong, Seo Jung, Zask, Arie, Liu, Hengrui, Kim, Sungsoo, Melore, Schuyler, Nair, Manoj S., Huang, Yaoxing, Tay, Nicholas E.S., Rovis, Tomislav, Yang, Hee Won, Stockwell, Brent R., Ho, David D., Chavez, Alejandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457602/
https://ncbi.nlm.nih.gov/pubmed/32869020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.29.272864
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