A simplified cell-based assay to identify coronavirus 3CL protease inhibitors

We describe a mammalian cell-based assay capable of identifying coronavirus 3CL protease (3CLpro) inhibitors without requiring the use of live virus. By enabling the facile testing of compounds across a range of coronavirus 3CLpro enzymes, including the one from SARS-CoV-2, we are able to quickly id...

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Publié dans:bioRxiv
Auteurs principaux: Resnick, Samuel J., Iketani, Sho, Hong, Seo Jung, Zask, Arie, Liu, Hengrui, Kim, Sungsoo, Melore, Schuyler, Nair, Manoj S., Huang, Yaoxing, Tay, Nicholas E.S., Rovis, Tomislav, Yang, Hee Won, Stockwell, Brent R., Ho, David D., Chavez, Alejandro
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457602/
https://ncbi.nlm.nih.gov/pubmed/32869020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.29.272864
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