Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice

Whereas the mode of action of lamivudine (LAM) against hepatitis B virus (HBV) is well established, the inhibition mechanism(s) of interferon alpha (IFN-α) is less completely defined. To advance our understanding, we mathematically modeled HBV kinetics during 14-day pegylated IFN-α-2a (pegIFN), LAM,...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Reinharz, Vladimir, Ishida, Yuji, Tsuge, Masataka, Durso-Cain, Karina, Chung, Tje Lin, Tateno, Chise, Perelson, Alan S., Uprichard, Susan L., Chayama, Kazuaki, Dahari, Harel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2021
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223956/
https://ncbi.nlm.nih.gov/pubmed/33910953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00492-20
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