PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

BACKGROUND: T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and are predicted to be sensitive to gamma-secretase inhibitors. We...

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Publicat a:J Hematol Oncol
Autors principals: Govaerts, Inge, Prieto, Cristina, Vandersmissen, Charlien, Gielen, Olga, Jacobs, Kris, Provost, Sarah, Nittner, David, Maertens, Johan, Boeckx, Nancy, De Keersmaecker, Kim, Segers, Heidi, Cools, Jan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223323/
https://ncbi.nlm.nih.gov/pubmed/34167562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-021-01114-1
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