Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia that is most frequent in children and is characterized by the presence of few chromosomal rearrangements and 10 to 20 somatic mutations in protein-coding regions at diagnosis. The majority of T-ALL cases harbor activating mutation...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Albertí-Servera, Llucia, Demeyer, Sofie, Govaerts, Inge, Swings, Toon, De Bie, Jolien, Gielen, Olga, Brociner, Marco, Michaux, Lucienne, Maertens, Johan, Uyttebroeck, Anne, De Keersmaecker, Kim, Boeckx, Nancy, Segers, Heidi, Cools, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885827/
https://ncbi.nlm.nih.gov/pubmed/32812017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006996
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