Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor

Factor VIII (fVIII) is a procoagulant protein that binds to activated factor IX (fIXa) on platelet surfaces to form the intrinsic tenase complex. Due to the high immunogenicity of fVIII, generation of antibody inhibitors is a common occurrence in patients during hemophilia A treatment and spontaneou...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ronayne, Estelle K., Peters, Shaun C., Gish, Joseph S., Wilson, Celena, Spencer, H. Trent, Doering, Christopher B., Lollar, Pete, Spiegel, P. Clint, Childers, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223065/
https://ncbi.nlm.nih.gov/pubmed/34177966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.697602
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