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Resistance Mutations to BTK Inhibitors Originate From the NF-κB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway

Since the first clinical report in 2013, inhibitors of the intracellular kinase BTK (BTKi) have profoundly altered the treatment paradigm of B cell malignancies, replacing chemotherapy with targeted agents in patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenstr...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Smith, C. I. Edvard, Burger, Jan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222783/
https://ncbi.nlm.nih.gov/pubmed/34177947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.689472
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