Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ

Ischemic heart disease is a leading cause of heart failure and hypoxia inducible factor 1 (HIF1) is a key transcription factor in the response to hypoxic injury. Our lab has developed a mouse model in which a mutated, oxygen-stable form of HIF1α (HIF-PPN) can be inducibly expressed in cardiomyocytes...

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Опубликовано в: :Sci Rep
Главные авторы: Williams, Allison Lesher, Walton, Chad B., Pinell, Blake, Khadka, Vedbar S., Dunn, Brandyn, Lee, Katie, Anagaran, M. C. Therese, Avelar, Abigail, Shohet, Ralph V.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222303/
https://ncbi.nlm.nih.gov/pubmed/34162925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92426-2
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