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Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that results from autoreactive T cells destroying the insulin-producing pancreatic beta (β) cells. The development of T1DM is associated with the deficiency of coinhibitory immune checkpoint ligands (e.g., PD-L1, CD86, and Gal-9) in β c...

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Bibliografiska uppgifter
I publikationen:Adv Mater
Huvudupphovsmän: Au, Kin Man, Medik, Yusra, Ke, Qi, Tisch, Roland, Wang, Andrew Z.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222180/
https://ncbi.nlm.nih.gov/pubmed/33963786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.202101253
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