Nanoparticle co-delivery of wortmannin and cisplatin synergistically enhances chemoradiotherapy and reverses platinum resistance in ovarian cancer models

Most ovarian cancer patients respond well to initial platinum-based chemotherapy. However, within a year, many patients experience disease recurrence with a platinum resistant phenotype that responds poorly to second line chemotherapies. As a result, new strategies to address platinum resistant ovar...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biomaterials
Prif Awduron: Zhang, Maofan, Hagan, C. Tilden, Min, Yuangzeng, Foley, Hayley, Tian, Xi, Yang, Feifei, Mi, Yu, Au, Kin Man, Medik, Yusra, Roche, Kyle, Wagner, Kyle, Rodgers, Zachary, Wang, Andrew Z.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911411/
https://ncbi.nlm.nih.gov/pubmed/29631163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.03.055
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