Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability

Membrane protein structures provide atomic level insight into essential biochemical processes and facilitate protein structure-based drug design. However, the inherent instability of these bio-macromolecules outside lipid bilayers hampers their structural and functional study. Detergent micelles can...

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Publicado no:Acta Biomater
Main Authors: Sadaf, Aiman, Kim, Seonghoon, Bae, Hyoung Eun, Wang, Haoqing, Nygaard, Andreas, Uegaki, Yuki, Du, Yang, Munk, Chastine F., Katsube, Satoshi, Lee, Hyun Sung, Bae, Jungnam, Choi, Chul Won, Choi, Hee-Jung, Byrne, Bernadette, Gellman, Samuel H., Guan, Lan, Loland, Claus J., Kobilka, Brian K., Im, Wonpil, Chae, Pil Seok
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222176/
https://ncbi.nlm.nih.gov/pubmed/33933694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2021.04.043
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