Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non-cancerous OXPHOS and thus suffer from a limited th...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Nelson, Margaret AM, McLaughlin, Kelsey L, Hagen, James T, Coalson, Hannah S, Schmidt, Cameron, Kassai, Miki, Kew, Kimberly A, McClung, Joseph M, Neufer, P Darrell, Brophy, Patricia, Vohra, Nasreen A, Liles, Darla, Cabot, Myles C, Fisher-Wellman, Kelsey H
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2021
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221809/
https://ncbi.nlm.nih.gov/pubmed/34132194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63104
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