Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non-cancerous OXPHOS and thus suffer from a limited th...

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Pubblicato in:eLife
Autori principali: Nelson, Margaret AM, McLaughlin, Kelsey L, Hagen, James T, Coalson, Hannah S, Schmidt, Cameron, Kassai, Miki, Kew, Kimberly A, McClung, Joseph M, Neufer, P Darrell, Brophy, Patricia, Vohra, Nasreen A, Liles, Darla, Cabot, Myles C, Fisher-Wellman, Kelsey H
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221809/
https://ncbi.nlm.nih.gov/pubmed/34132194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63104
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