Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non-cancerous OXPHOS and thus suffer from a limited th...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nelson, Margaret AM, McLaughlin, Kelsey L, Hagen, James T, Coalson, Hannah S, Schmidt, Cameron, Kassai, Miki, Kew, Kimberly A, McClung, Joseph M, Neufer, P Darrell, Brophy, Patricia, Vohra, Nasreen A, Liles, Darla, Cabot, Myles C, Fisher-Wellman, Kelsey H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221809/
https://ncbi.nlm.nih.gov/pubmed/34132194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63104
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