Lactate and IL6 define separable paths of inflammatory metabolic adaptation

Lactate is an end point of Warburg-type metabolism found in inflammatory macrophages. Recently, lactate was shown to modify histones of lipopolysaccharide (LPS)–activated macrophages in a time-dependent way and promote the expression of genes linked to tissue repair, including arginase-1 (Arg1). We...

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Vydáno v:Sci Adv
Hlavní autoři: Dichtl, Stefanie, Lindenthal, Laura, Zeitler, Leonie, Behnke, Kristina, Schlösser, Daniela, Strobl, Birgit, Scheller, Jürgen, El Kasmi, Karim C., Murray, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221612/
https://ncbi.nlm.nih.gov/pubmed/34162546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg3505
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