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Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit
Despite promising efficacy, the clinical use of the anti-tubercular therapeutic bedaquiline has been restricted due to safety concerns. To date, limited SAR studies have focused on the quinoline ring (A-ring), and as such, we set out to explore modifications within this region in an attempt to disco...
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| Publicat a: | RSC Med Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
RSC
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8221263/ https://ncbi.nlm.nih.gov/pubmed/34223160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00063b |
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