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Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit

Despite promising efficacy, the clinical use of the anti-tubercular therapeutic bedaquiline has been restricted due to safety concerns. To date, limited SAR studies have focused on the quinoline ring (A-ring), and as such, we set out to explore modifications within this region in an attempt to disco...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Barbaro, Lisa, Nagalingam, Gayathri, Triccas, James A., Tan, Lendl, West, Nicholas P., Baell, Jonathan B., Priebbenow, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221263/
https://ncbi.nlm.nih.gov/pubmed/34223160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00063b
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