The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes

BACKGROUND: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated. METHODS: We used a population-based case-...

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Vydáno v:EBioMedicine
Hlavní autoři: Zhao, Lue Ping, Papadopoulos, George K, Lybrand, Terry P., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Persson, Martina, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Rich, Stephen S., Lernmark, Åke
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220560/
https://ncbi.nlm.nih.gov/pubmed/34153873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103431
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