The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes

BACKGROUND: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated. METHODS: We used a population-based case-...

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Udgivet i:EBioMedicine
Main Authors: Zhao, Lue Ping, Papadopoulos, George K, Lybrand, Terry P., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Persson, Martina, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Rich, Stephen S., Lernmark, Åke
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220560/
https://ncbi.nlm.nih.gov/pubmed/34153873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103431
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