Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children

HLA-DQA1 and -DQB1 are strongly associated with type 1 diabetes (T1D), and DQ8.1 and DQ2.5 are major risk haplotypes. Next-generation targeted sequencing of HLA-DQA1 and -DQB1 in Swedish newly diagnosed 1- to 18 year-old patients (n = 962) and control subjects (n = 636) was used to construct abbrevi...

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Udgivet i:Diabetes
Main Authors: Zhao, Lue Ping, Papadopoulos, George K., Kwok, William W., Moustakas, Antonis K., Bondinas, George P., Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Lernmark, Åke
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2020
Fag:
Genetics/Genomes/Proteomics/Metabolomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306123/
https://ncbi.nlm.nih.gov/pubmed/32245799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0075
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