Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon associated with significantly decreased drug bioavailabil...

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Udgivet i:Front Pharmacol
Main Authors: Martinec, Ondrej, Biel, Carin, de Graaf, Inge A. M., Huliciak, Martin, de Jong, Koert P., Staud, Frantisek, Cecka, Filip, Olinga, Peter, Vokral, Ivan, Cerveny, Lukas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220149/
https://ncbi.nlm.nih.gov/pubmed/34177592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.684156
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