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UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures and how they are formed remain...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8219777/ https://ncbi.nlm.nih.gov/pubmed/34158508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24201-w |
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