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Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Peripheral infections followed by systemic inflammation may contribute to the onset of Alzheimer`s disease (AD) and accelerate the disease progression later in life. Yet, the impact of systemic inflammation on the plasma and brain tissue metabolome and lipidome in AD has not been investigated. In th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Puris, Elena, Kouřil, Štěpán, Najdekr, Lukáš, Loppi, Sanna, Korhonen, Paula, Kanninen, Katja M., Malm, Tarja, Koistinaho, Jari, Friedecký, David, Gynther, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219693/
https://ncbi.nlm.nih.gov/pubmed/34158563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92602-4
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