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Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Peripheral infections followed by systemic inflammation may contribute to the onset of Alzheimer`s disease (AD) and accelerate the disease progression later in life. Yet, the impact of systemic inflammation on the plasma and brain tissue metabolome and lipidome in AD has not been investigated. In th...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Puris, Elena, Kouřil, Štěpán, Najdekr, Lukáš, Loppi, Sanna, Korhonen, Paula, Kanninen, Katja M., Malm, Tarja, Koistinaho, Jari, Friedecký, David, Gynther, Mikko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219693/
https://ncbi.nlm.nih.gov/pubmed/34158563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92602-4
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