PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases, bio-energetics demand increases and becomes reliant upon fatty acid oxidation as a source of energy. Defective fatty acid oxidation and mitochondrial dysfunctions correlate with hippocampal neurodegeneration and...

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Pubblicato in:Glia
Autori principali: Konttinen, Henna, Gureviciene, Irina, Oksanen, Minna, Grubman, Alexandra, Loppi, Sanna, Huuskonen, Mikko T., Korhonen, Paula, Lampinen, Riikka, Keuters, Meike, Belaya, Irina, Tanila, Heikki, Kanninen, Katja M., Goldsteins, Gundars, Landreth, Gary, Koistinaho, Jari, Malm, Tarja
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526864/
https://ncbi.nlm.nih.gov/pubmed/30453390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23534
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