NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a central regulator of cellular stress responses and its transcriptional activation promotes multiple cellular defense and survival mechanisms. The loss of NRF2 has been shown to increase oxidative and proteotoxic stress, two key pathological fea...

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Detalhes bibliográficos
Publicado no:Aging Dis
Main Authors: Anandhan, Annadurai, Nguyen, Nhat, Syal, Arjun, Dreher, Luke A, Dodson, Matthew, Zhang, Donna D, Madhavan, Lalitha
Formato: Artigo
Idioma:Inglês
Publicado em: JKL International LLC 2021
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Orginal Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219498/
https://ncbi.nlm.nih.gov/pubmed/34221542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2021.0511
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