A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target

[Image: see text] Inhibition of inflammasome and pyroptotic pathways are promising strategies for clinical treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome pyrin domain-containing 3 (NLRP3) protein, has shown encouraging results in animal...

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Publicat a:ACS Chem Biol
Autors principals: Kennedy, Cassandra R., Goya Grocin, Andrea, Kovačič, Tristan, Singh, Ravi, Ward, Jennifer A., Shenoy, Avinash R., Tate, Edward W.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218299/
https://ncbi.nlm.nih.gov/pubmed/34003636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.1c00218
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