DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation

Pressure overload leads to a hypertrophic milieu that produces deleterious cardiac dysfunction. Inflammation is a key pathophysiological mechanism underpinning myocardial hypertrophy. DL-3-n-butylphthalide (NBP), a neuroprotective agent, also has potent cardioprotective effects. In this study, the p...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Han, Bingjiang, Xu, Jiajun, Shi, Xiaowen, Zheng, Zhanxiong, Shi, Fengjie, Jiang, Fenfen, Han, Jibo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217660/
https://ncbi.nlm.nih.gov/pubmed/34168567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.688140
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