Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway

INTRODUCTION: Schisandrin B (SchB), the main active constituent in Schisandra chinensis, has antioxidant activities. Endothelial dysfunction leads to various cardiovascular diseases. Oxidative stress is a crucial pathophysiological mechanism underpinning endothelial dysfunction. METHODS: We elucidat...

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發表在:Drug Des Devel Ther
Main Authors: Han, Jibo, Shi, Xiaowen, Zheng, Zhanxiong, Zhang, Bin, Shi, Fengjie, Jiang, Liqin, Xu, Jianjiang
格式: Artigo
語言:Inglês
出版: Dove Medical Press 2018
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255115/
https://ncbi.nlm.nih.gov/pubmed/30538426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S184245
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