Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway

INTRODUCTION: Schisandrin B (SchB), the main active constituent in Schisandra chinensis, has antioxidant activities. Endothelial dysfunction leads to various cardiovascular diseases. Oxidative stress is a crucial pathophysiological mechanism underpinning endothelial dysfunction. METHODS: We elucidat...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Han, Jibo, Shi, Xiaowen, Zheng, Zhanxiong, Zhang, Bin, Shi, Fengjie, Jiang, Liqin, Xu, Jianjiang
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255115/
https://ncbi.nlm.nih.gov/pubmed/30538426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S184245
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