Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Tan, Timothy J. C., Yuan, Meng, Kuzelka, Kaylee, Padron, Gilberto C., Beal, Jacob R., Chen, Xin, Wang, Yiquan, Rivera-Cardona, Joel, Zhu, Xueyong, Stadtmueller, Beth M., Brooke, Christopher B., Wilson, Ian A., Wu, Nicholas C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217500/
https://ncbi.nlm.nih.gov/pubmed/34155209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24123-7
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