Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation

Ischemic stroke is one of the most common neurological diseases. However, the impact of ischemic stroke on human cerebral tissue remains largely unknown due to a lack of ischemic human brain samples. In this study, we applied cerebral organoids derived from human induced pluripotent stem cells to ev...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Iwasa, Naoki, Matsui, Takeshi K., Iguchi, Naohiko, Kinugawa, Kaoru, Morikawa, Naritaka, Sakaguchi, Yoshihiko M., Shiota, Tomo, Kobashigawa, Shinko, Nakanishi, Mari, Matsubayashi, Masaya, Nagata, Riko, Kikuchi, Sotaro, Tanaka, Tatsuhide, Eura, Nobuyuki, Kiriyama, Takao, Izumi, Tesseki, Saito, Kozue, Kataoka, Hiroshi, Saito, Yuichi, Kimura, Wataru, Wanaka, Akio, Nishimura, Yuhei, Mori, Eiichiro, Sugie, Kazuma
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Cellular Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217463/
https://ncbi.nlm.nih.gov/pubmed/34168538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.605030
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