CD44 alternative splicing senses intragenic DNA methylation in tumors via direct and indirect mechanisms

DNA methylation (meDNA) is a modulator of alternative splicing, and splicing perturbations are involved in tumorigenesis nearly as frequently as DNA mutations. However, the impact of meDNA on tumorigenesis via splicing-mediated mechanisms has not been thoroughly explored. Here, we found that HCT116...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Batsché, Eric, Yi, Jia, Mauger, Oriane, Kornobis, Etienne, Hopkins, Benjamin, Hanmer-Lloyd, Charlotte, Muchardt, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216461/
https://ncbi.nlm.nih.gov/pubmed/34086943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab437
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