microRNA27a-3p mediates reduction of the Wnt antagonist sFRP-1 in systemic sclerosis

Systemic Sclerosis (SSc) is an autoimmune connective tissue disease that leads to skin and lung fibrosis. The Wnt pathway is clearly elevated in SSc and is pro-fibrotic via activation of canonical Wnt signalling. sFRP-1 is a Wnt antagonist that acts as a negative regulator of Wnt signalling. We soug...

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Publicat a:Epigenetics
Autors principals: Henderson, John, Wilkinson, Sarah, Przyborski, Stefan, Stratton, Richard, O’Reilly, Steven
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216176/
https://ncbi.nlm.nih.gov/pubmed/32965161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1827715
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