Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

BACKGROUND: Wnt signaling is a critical determinant for the maintenance and differentiation of stem/progenitor cells, including trophoblast stem cells during placental development. Hyperactivation of Wnt signaling has been shown to be associated with human trophoblast diseases. However, little is kn...

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Pubblicato in:BMC Biol
Autori principali: Bao, Haili, Liu, Dong, Xu, Yingchun, Sun, Yang, Mu, Change, Yu, Yongqin, Wang, Chunping, Han, Qian, Liu, Sanmei, Cai, Han, Liu, Fan, Kong, Shuangbo, Deng, Wenbo, Cao, Bin, Wang, Haibin, Wang, Qiang, Lu, Jinhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592576/
https://ncbi.nlm.nih.gov/pubmed/33109217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00883-4
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